The concomitant administration on the protease inhibitor ritonavir substantially improves serum concentrations of sildenafil (11-fold boost in AUC). If VIAGRA is prescribed to sufferers having ritonavir, warning need to be employed. Details from topics subjected to significant systemic amounts of sildenafil are confined.
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Even though the interaction concerning other protease inhibitors and sildenafil hasn't been examined, their concomitant use is expected to extend sildenafil ranges.
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